化合物FT011 T7298

Product Introduction
Bioactivity


英文名: FT011

描述: FT011 是抗纤维化剂，能够抑制胶原蛋白 I 和 III 的 mRNA 表达，减少胶原蛋白合成。

动物实验: Homozygous Ren-2 rats were randomized to receive streptozotocin or vehicle then further randomized to FT011 (200 mg/kg/day) or vehicle treatment for 6 weeks. Prior to tissue collection, cardiac function was assessed via echocardiography and cardiac catheterization. Total collagen deposition and cardiomyocyte hypertrophy were assessed by picrosirius red and haematoxylin and eosin staining, respectively. Macrophage interstitial infiltration and type I and III collagen were quantitated by immunostaining[1].

体内活性: A direct anti-fibrotic agent, FT011, attenuates cardiac remodelling and dysfunction in experimental diabetic cardiomyopathy[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 29 mg/mL (82.54 mM)


关键字: Inhibitor | FT-011 | FT011 | FT 011 | inhibit

相关库: Drug Repurposing Compound Library | ReFRAME Related Library | Clinical Compound Library | Bioactive Compounds Library Max | NO PAINS Compound Library | Covalent Inhibitor Library | Bioactive Compound Library

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