恩氯米芬柠檬酸盐 T7313

Product Introduction
Bioactivity


英文名: Enclomiphene citrate

描述: Enclomiphene citrate (trans-Clomiphene citrate) 是口服具有活力的 oestrogen receptor 拮抗剂，具有抗雌激素活性。

动物实验: Two parallel randomised, double-blind, double-dummy, placebo-controlled, multicentre, phase III studies were undertaken to evaluate two doses of enclomiphene citrate vs testosterone gel on total testosterone (TT), LH, FSH, and sperm counts in overweight men aged 18-60 years with secondary hypogonadism. Men were screened and enrolled in the trials (ZA-304 and ZA-305). All enrolled men had early morning serum TT levels in the low or low normal range (≤300 ng/dL; ≤10.4 nmol/L) and had low or normal LH (<9.4 IU/L) levels measured on two separate occasions 2-10 days apart. Serum samples were obtained over the course of the study to determine relevant hormone levels at baseline and after 16 weeks of treatment. Men provided semen samples twice to enroll at the beginning and twice at the end of the study[1].

体内活性: total testosterone (TT) levels increased between baseline and after 16 weeks of treatment in all the treatment groups. FSH and LH levels increased in the enclomiphene citrate groups and decreased in the testosterone gel group at 16 weeks. Enclomiphene citrate maintained sperm concentration in the normal range over the treatment period, while there was a marked reduction in spermatogenesis in the testosterone gel group[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (83.60 mM)


关键字: testosterone deficiency | Inhibitor | Enclomiphene citrate | trans-Clomiphene | testosterone | Hypogonadal | trans-Clomiphene Citrate | hormone | ovarian dysfunction | Enclomifene Citrate | Enclomiphene Citrate | inhibit | Enclomifene | Clomiphene Citrate | hypogonadism | (E)-Clomiphene | Estrogen Receptor/ERR | estrogen receptor modulator | Enclomiphene

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相关库: Drug Repurposing Compound Library | Approved Drug Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Clinical Compound Library | Anti-Ovarian Cancer Compound Library | Inhibitor Library | Anti-Cancer Clinical Compound Library | Nuclear Receptor Compound Library | Anti-Cancer Approved Drug Library

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