化合物RSV604 T7353
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 676128-63-5 | ¥1,590.00 | 询底价 |
5 mg | 676128-63-5 | ¥496.00 | 询底价 |
1 mg | 676128-63-5 | ¥218.00 | 询底价 |
10 mg | 676128-63-5 | ¥818.00 | 询底价 |
2 mg | 676128-63-5 | ¥297.00 | 询底价 |
1 mL | 676128-63-5 | ¥546.00 | 询底价 |
100 mg | 676128-63-5 | ¥4,350.00 | 询底价 |
50 mg | 676128-63-5 | ¥2,720.00 | 询底价 |
Product Introduction
Bioactivity
英文名: RSV604
描述: RSV604 ((S)-1-(2-Fluorophenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)urea) 是一种呼吸道合胞病毒抑制剂,可与 RSV 核蛋白结合,靶向核衣壳蛋白的 Kd 值为 1.6 μM。它对 RSV A 和 B 亚型的众多临床分离株有亚微摩尔活性,EC50平均值为 0.8 μM。
体外活性: RSV-604 increases viability of RSV-infected HEp-2 cells (EC50 = 0.86 μM) and inhibits RSV replication in human airway epithelial (HAE) cell monolayers following mucosal inoculation[1].
体内活性: RSV604 resistance mutations in the N protein. RSV604 engaged in two different MoAs in HeLa cells, inhibiting both RSV RNA synthesis and the infectivity of released virus. RSV604 did not inhibit viral RNA synthesis in the RSV subgenomic replicon cells or in the cell-free RNP assay, suggesting that it might act prior to viral replication complex formation. RSV604 did not alter N protein localization in the infected cells[2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 195 mg/mL (502.07 mM)
关键字: virus | RSV604 | Respiratory syncytial virus | A 60444 | respiratory | protein | inhibit | RSV | RSV 604 | syncytial | A-60444 | RSV-604 | Inhibitor | A60444 | nucleocapsid
相关产品: Lumicitabine | Ac-CoA Synthase Inhibitor1 | VV116 | GS-443902 | Rostafuroxin | KIN101 | 4-Methoxycinnamaldehyde | RSV L-protein-IN-4 | Rilematovir | RSV L-protein-IN-2
相关库: Drug Repurposing Compound Library | ReFRAME Related Library | Clinical Compound Library | Bioactive Compounds Library Max | Inhibitor Library | NO PAINS Compound Library | Covalent Inhibitor Library | Anti-Viral Compound Library | Anti-Infection Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途