化合物EB1 T73582

Product Introduction
Bioactivity


英文名: EB1

描述: EB1 是一种具有有效性和选择性的 MNK 激酶抑制剂，对 MNK1和 MNK2 具有抑制作用 IC50 分别为 0.69 μM 和 9.4 μM。EB1 抑制癌细胞的生长，促进细胞凋亡，抑制 eIF4E 磷酸化。

体外活性: EB1, in a dose-dependent manner (1.3-40 μM; 24 hours), inhibits the phosphorylation of eIF4E[1].At doses of 2.5-40 μM (72 hours), EB1 exhibits dose-dependent cytotoxicity against tumor cells and induces apoptosis[1].When directly acting on MNK kinase at concentrations of 5 μM, 10 μM, and 20 μM (24 hours), EB1 does not interfere with the activation of upstream signals such as p38 activation (p-p38) and the phosphorylation of its downstream effector HSP27[1].Compound 14 (EB1) inhibits cancer cells HepG2 and MCF-7 with IC50 values of 0.74 μM and 5.18 μM, respectively[2].

存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (174.62 mM)


相关产品: DS12881479 | CGP 57380 | QL-X-138 | QL-X-138 HCl | Tomivosertib | AZ7550 | ETC-206 | SLV-2436 | MK2-IN-3 hydrate

相关库: Kinase Inhibitor Library | Inhibitor Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途