化合物Revefenacin T7392

Product Introduction
Bioactivity


英文名: Revefenacin

描述: Revefenacin (TD-4208) 是一种mAChR 拮抗剂，在M3受体上具有高亲和力，Ki 值为 0.18 nM。

体内活性: In anesthetized dogs, TD-4208, along with tiotropium and glycopyrronium, produced sustained inhibition of acetylcholine-induced bronchoconstriction for up to 24 hours. In anesthetized rats, inhaled TD-4208 exhibited dose-dependent 24-hour bronchoprotection against methacholine-induced bronchoconstriction. The estimated 24-hour potency (expressed as concentration of dosing solution) was 45.0 μg/ml[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 125 mg/mL (209.12 mM)


关键字: GSK 1160724 | inhibit | Muscarinic acetylcholine receptor | Inhibitor | mAChR | TD4208 | Revefenacin | TD 4208 | GSK-1160724

相关产品: Harmalol | Terfenadine | YM-46303 | Glycopyrrolate | Niazimicin | Tacrine hydrochloride (hydrate) | MHP 133 | Disopyramide | UP202-56 | A-867744

相关库: FDA-Approved Drug Library | Anti-Neurodegenerative Disease Compound Library | Drug Repurposing Compound Library | Anti-COVID-19 Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Inhibitor Library | Anti-Alzheimer's Disease Compound Library | NO PAINS Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途