化合物ONO-7300243 T7393

Product Introduction
Bioactivity


英文名: ONO-7300243

描述: ONO-7300243 是溶血磷脂酸受体 1 (LPA1)拮抗剂，IC50为 0.16 μM。

体内活性: The oral administration of ONO-7300243 (17a) to determine its effect on rat IUP. Compound 17a inhibited the LPA-induced IUP increase in a dose-dependent manner (ID50 = 11.6 mg/kg p.o.) up to 1 h after dosing. Significant effects were observed at 10 and 30 mg/kg (p < 0.05 vs vehicle). ONO-7300243 (17a) (30 mg/kg, p.o.) led to a significant decrease in the IUP in conscious rats without LPA stimulation compared with the vehicle without affecting the mean blood pressure (MBP)[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 100 mg/mL (216.66 mM)


关键字: ONO-7300243 | inhibit | Inhibitor | ONO 7300243 | LPL Receptor | ONO7300243 | Lysophospholipid Receptor

相关产品: AM095 free acid | LPA2 antagonist 2 | DBIBB | Tetradecyl Phosphonate | LPA1 receptor antagonist 1 | BMS-986278 | 1-Oleoyl lysophosphatidic acid sodium | AM966 | LX-1031 | Ki16198

相关库: Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Inhibitor Library | GPCR Compound Library | Anti-Fibrosis Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途