化合物RRX-001 T7400

Product Introduction
Bioactivity


英文名: RRX-001

描述: RRx-001 是一种低氧选择性的表观遗传因子，被用作放射或化疗敏感剂，能诱发凋亡，克服骨髓瘤的耐药性。它是G6PD 的有效抑制剂，具有抗疟、抗癌活性。它是免疫检查点的抑制剂，可下调CD47和SIRP-α。

体外活性: RRx-001 inhibited the growth of colon cancer cells (HCT 116) and decreased levels of the DNA methyltransferases DNMT1 and DNMT3a in a time and dose-dependent manner. Treatment of HCT 116 cells with 0.5 μM RRx-001 for 24 h significantly increased transcripts of interferon (IFN)-responsive genes and this induction was sustained for up to 4 weeks after transient exposure to RRx-001. RRx-001 increased secretion of type I and III IFNs by HCT 116 cells, and these IFNs were confirmed to be bioactive. Transcription of endogenous retrovirus ERV-Fc2 and LTRs from the ERV-L family (MLT2B4 and MLT1C49) was induced by RRx-001[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 100 mg/mL (373.11 mM)


关键字: RRX 001 | Parasite | RRx-001 | Apoptosis | Inhibitor | RRX001 | inhibit | RRX-001

相关产品: DBEQ | Pyridinium bisretinoid A2E TFA | Licofelone | HPOB | PHA-767491 hydrochloride | Tributyrin | Volasertib | ARS-853 | Thapsigargin | Ripretinib

相关库: Drug Repurposing Compound Library | Anti-Cancer Metabolism Compound Library | ReFRAME Related Library | Anti-Cancer Drug Library | Anti-Metabolism Disease Compound Library | Inhibitor Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Active Compound Library | Anti-Parasitic Compound Library | NO PAINS Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途