3-(3-羟基苯基)丙酸 T7437
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
100 mg | 621-54-5 | ¥99.00 | 询底价 |
Product Introduction
Bioactivity
英文名: 3-(3-Hydroxyphenyl)propionic Acid
描述: 3-(3-Hydroxyphenyl)propionic Acid (m-Hydroxyphenylpropionic acid) 是一种黄酮类代谢产物,由人体微生物区系形成,具有舒张血管的特性。
细胞实验: RAW264.7 cells or nonadherent bone marrow cells were cultured in 96‐well plates (2?×?10^4cells/well) in the presence or absence of 50?ng/ml of RANKL.?Cells were treated with HA at four different concentrations, 0.01×, 0.1×, 1×, and 10×, with 1× equivalent to concentration of 60?μg/dl of HA free form appeared in blood after 10% BB supplemental diet in rats.?Four different concentrations of 3‐3‐PPA or 3‐(4‐hydroxyphenyl) propionic acid (3–4‐PPA), 0.1×, 1×, 10×, and 100×, with 1× equivalent to concentration of 10?μg/dl of 3‐3‐PPA or 3–4‐PPA free form appeared in blood after 10% BB supplemental diet in rats.?After 4 days for RAW264.7 cell cultures and 5 days for bone marrow cell cultures, the cells were ?xed with 4% paraformaldehyde and stained for tartrate‐resistant acid phosphatase (TRAPase) activity using a TRAPase Staining Kit .?TRAP‐positive cells containing >3 nuclei in each well were counted as osteoclasts under an epifluorescent microscope[1]
体外活性: 3-(3-hydroxyphenyl) propionic acid (3-3-PPA) and hippuric acid (HA), had dose-dependent suppressive effects on osteoclastogenesis and osteoclast resorptive activity in Corning osteo-assay plates.?Signaling pathway analysis showed that after pretreatment with HA or 3-3-PPA, RANKL-stimulated increase of osteoclastogenic markers, such as nuclear factor of activated T-cells, cytoplasmic 1 and matrix metallopeptidase 9 gene/protein expression were blunted.?Inhibitory effects of HA and 3-3-PPA on osteoclastogenesis utilized RANKL/RANK independent mediators[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 33mg/mL(198.59mM)
关键字: aortic | Inhibitor | rings | Endogenous Metabolite | 3(3Hydroxyphenyl)propionic Acid | metabolite | 3 (3 Hydroxyphenyl)propionic Acid | 3-(3-Hydroxyphenyl)propionic Acid | microflora | inhibit | rat | vasodilatory | flavonoid
相关产品: D-Galactose | Heparin | (S)-(-)-Phenylethanol | Cotinine | Erythronic acid potassium | 2,3-Diaminopropionic acid | DL-O-Phosphoserine | L-Methionine sulfoxide | 4-Hydroxybenzoic acid | Aminomalonic acid
相关库: Tobacco Monomer Library | Bioactive Compounds Library Max | Traditional Chinese Medicine Monomer Library | Anti-COVID-19 Traditional Chinese Medicine Compound Library | Miao medicine Compound Library | Microbial Natural Product Library | Gut Microbial Metabolite Library | NO PAINS Compound Library | Bioactive Compound Library | Natural Product Library
3-(3-羟基苯基)丙酸 T7437信息由TargetMol中国为您提供,如您想了解更多关于3-(3-羟基苯基)丙酸 T7437报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途