胍基丙酸 T7535
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 g | 353-09-3 | ¥1,450.00 | 询底价 |
25 mg | 353-09-3 | ¥198.00 | 询底价 |
100 mg | 353-09-3 | ¥428.00 | 询底价 |
10 mg | 353-09-3 | ¥137.00 | 询底价 |
500 mg | 353-09-3 | ¥987.00 | 询底价 |
200 mg | 353-09-3 | ¥625.00 | 询底价 |
50 mg | 353-09-3 | ¥282.00 | 询底价 |
5 mg | 353-09-3 | ¥108.00 | 询底价 |
Product Introduction
Bioactivity
英文名: RGX-202
描述: RGX-202 (β-GPA) 是口服有活性的SLC6A8转运蛋白抑制剂。它在体内外均能够强烈地抑制肌酸输入,降低细胞内磷酸肌酸和 ATP 水平,诱导肿瘤凋亡,可于研究肿瘤。
动物实验: The following animal groups were used for the experiment: (1) mice that were not subjected to injections (n = 10)—this group was used only for physiological tests and were not killed after the experiment;?(2) saline-treated mice (n = 8)—the volume of injections was 200 μL;?and (3) β-GPA-treated mice (n = 8)—concentration of β-GPA was 1 mg/kg/day.?The volume of injections was 200 μL.Injections were performed 3 times a week for 3 weeks.?The mice's weight and the total amount of consumed food and water were measured daily.?Once a week, a string test was performed.?Measurements of the oxygen consumption rates of live animals and the open field test were performed after the course of injections.?After 3 weeks, the mice were killed;?brain dissection was performed to extract the cortex and the ventral midbrain (VMB) for quantitative real-time polymerase chain reaction (qRT-PCR) analysis[2].
体外活性: 3-Guanidinopropionic acid evokes a shift from glycolytic to oxidative metabolism, increased cellular glucose uptake, and increased fatigue tolerance[1]
体内活性: 3-Guanidinopropionic Acid(β-GPA) downregulated the expression of the β-oxidation genes.?Administration of β-GPA in mice for 3 weeks improved the animals' physical strength and endurance health, ie, increased their physical strength and endurance and alleviated anxiety.?β-GPA might be considered an adaptogene affecting both the muscle and brain metabolism in mammals[2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : Slightly soluble
关键字: cancer | apoptosis | inhibit | beta-GPA | RGX-202 | creatine import | b-GPA | Inhibitor | RGX 202 | oral | mice | Endogenous Metabolite | RGX202
相关产品: Brazilin | Pinusolide | Beta-Hydroxyisovalerylshikonin | COH-SR4 | AMPK activator 2 | ML753286 | AMPK activator 13 | Icariside E4 | STO-609 | Kudinoside D
相关库: Anti-Hypertension Compound Library | Anti-Cancer Compound Library | Neuronal Differentiation Compound Library | Anti-Metabolism Disease Compound Library | Antidepressant Compound Library | Kinase Inhibitor Library | Inhibitor Library | Autophagy Compound Library | Orally Active Compound Library | Reprogramming Compound Library
胍基丙酸 T7535信息由TargetMol中国为您提供,如您想了解更多关于胍基丙酸 T7535报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途