加达西单抗 T77018
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mg | 2162134-62-3 | ¥2,320.00 | 询底价 |
10 mg | 2162134-62-3 | ¥9,570.00 | 询底价 |
25 mg | 2162134-62-3 | ¥14,200.00 | 询底价 |
5 mg | 2162134-62-3 | ¥5,990.00 | 询底价 |
50 mg | 2162134-62-3 | ¥18,900.00 | 询底价 |
100 mg | 2162134-62-3 | ¥25,800.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Garadacimab
描述: Garadacimab (CSL312) 是有效的全人 IgG4 单克隆抗体,针对活化因子 XII (FXIIa)。Garadacimab 可用于研究遗传性血管性水肿。。
体外活性: Garadacimab (CSL312) demonstrates high affinity to activated βFXIIa with a KD of 140 pM. In an activated partial thromboplastin time (aPTT) assay with human plasma, Garadacimab exhibits potency. Notably, it displays high selectivity over a panel of relevant human serine proteases, including FVIIa, FIXa, FXa, FXIa, kallikrein, tissue plasminogen activator, activated protein C, and urokinase plasminogen activator[2].
体内活性: In male and female cynomolgus monkeys, Garadacimab (0.5, 1, and 3 mg/kg i.v. and 6 and 20 mg/kg s.c. over 8 weeks) shows a dose-dependent increase in plasma concentrations[1]. Garadacimab exhibits an inhibitory effect on FXII-mediated kallikrein activity. Moreover, it induces a clear dose-dependent prolongation of activated partial thromboplastin time (aPTT) with no associated effect on the prothrombin time[1].
存储条件: store at low temperaturestore at -80°C
关键字: Garadacimab | CSL-312 | CSL 312
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途