化合物KY-226 T7704

Product Introduction
Bioactivity


英文名: KY-226

描述: KY-226 是选择性的，口服活性的和变构蛋白酪氨酸磷酸酶 1B 抑制剂，IC50=0.25 μM，且不激活 PPARγ 。它可以保护神经元免受脑缺血损伤。它通过增强胰岛素和瘦素信号传导发挥抗糖尿病和抗肥胖作用。

体内活性: In db/db mice, the oral administration of KY-226 (10 and 30 mg/kg/day, 4 weeks) significantly reduced plasma glucose and triglyceride levels as well as hemoglobin A1c values without increasing body weight gain, while pioglitazone exerted similar effects with increases in body weight gain.?KY-226 attenuated plasma glucose elevations in the oral glucose tolerance test.?KY-226 also increased pIR and phosphorylated Akt in the liver and femoral muscle.?In high-fat diet-induced obese mice, the oral administration of KY-226 (30 and 60 mg/kg/day, 4 weeks) decreased body weight gain, food consumption, and fat volume gain with increases in phosphorylated STAT3 in the hypothalamus.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 25 mg/mL (51.9 mM)


关键字: inhibit | anti-diabetic | leptin | ZO-1 | LPS | insulin | KY 226 | KY226 | phosphorylated | Akt | anti-obesity | PTP1B | Phosphatase | KY-226 | neurons | Inhibitor

相关产品: Ginkgolic acid C17:1 | BN82002 | AS1949490 | Razuprotafib | PROTAC PTPN2 degrader-2 TFA | NSC-87877 disodium | TD52 | Mulberrofuran G | Itacitinib adipate | BCI-215

相关库: Anti-Neurodegenerative Disease Compound Library | Glycometabolism Compound Library | Bioactive Compounds Library Max | Phosphatase Inhibitor Library | Inhibitor Library | Metabolism Compound Library | Endocrinology-Hormone Compound Library | Orally Active Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途