三磷酸尿苷 T7711
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
50 mg | 63-39-8 | ¥977.00 | 询底价 |
5 mg | 63-39-8 | ¥298.00 | 询底价 |
10 mg | 63-39-8 | ¥493.00 | 询底价 |
25 mg | 63-39-8 | ¥754.00 | 询底价 |
1 mg | 63-39-8 | ¥139.00 | 询底价 |
100 mg | 63-39-8 | ¥1,480.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Uridine triphosphate
描述: Uridine triphosphate (Uridine 5'-triphosphate) 是一种核苷酸,调节胰腺内分泌和外分泌、增殖、通道、转运体和细胞内信号传导的功能。
细胞实验: Proliferation was measured by immunoassay for bromodeoxyuridine incorporation into the pancreatic cell line PANC-1. Effect of UTP was assayed using selective P2 agonist and antagonist, small interfering RNA, intracellular signal inhibitors, and Western blot[1].
体外活性: Incubation of PANC-1 cells with UTP or MRS2768, a selective P2Y2 receptor agonist, resulted in a dose- and time-dependent increase of proliferation.?The messenger RNA transcript and protein of P2Y2 receptor were expressed in PANC-1 cells.?P2 receptor antagonist suramin and small interfering RNA against P2Y2 receptor significantly decreased the proliferative effect of UTP and MRS2768.?Activation of P2Y2 receptor by UTP transduced to phospholipase C, inositol 1,4,5-triphosphate (IP3), and protein kinase C. Uridine triphosphate-induced proliferation was mediated by protein kinase D, Src-family tyrosine kinase, Ca/calmodulin-dependent protein kinase II, phosphatidylinositol 3-kinase (PI3K), Akt, and phospholipase D. Uridine triphosphate increased phosphorylation of Akt through protein kinase C, Src-family tyrosine kinase, Ca/calmodulin-dependent protein kinase II, and PI3K[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: H2O : 150 mg/mL (309.83 mM)
关键字: Endogenous Metabolite | Uridine triphosphate | inhibit | Uridine Triphosphate | Inhibitor | Uridine
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途