化合物CGP 37849 T7720

Product Introduction
Bioactivity


英文名: CGP 37849

描述: CGP 37849 是一种竞争性口服活性 N-甲基-D-天冬氨酸 (NMDA) 受体拮抗剂（(Ki = 35 nM)），具有有效性。CGP 37849 是啮齿动物的抗惊厥药，也具有抗抑郁和抗焦虑的特性。

体外活性: Within the hippocampal slice in vitro, CGP 37849 demonstrates reversible and selective antagonism against NMDA-induced increases in the firing rate of CA1 pyramidal cells. In the presence of a low Mg2+ level medium, concentrations of CGP 37849 up to 10 μM effectively inhibit burst firing evoked in CA1 neurons by stimulating Schaffer collateral-commissural fibers, while leaving the magnitude of the initial population spike unaffected.[1]

体内活性: In vivo, oral administration to rats of CGP 37849 selectively blocks firing in hippocampal neurons induced by ionophoretically-applied NMDA, without affecting the responses to quisqualate or kainate.[1] Oral administration to mice of CGP 37849 suppresses maximal electroshock-induced seizures in mice with an ED50 of 21 mg/kg.[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 90.0 mg/mL (430.3 mM)
DMSO : Soluble


关键字: CGP 37849

相关产品: Orphenadrine hydrochloride | DNQX disodium salt | Ro 25-6981 | UBP551 | O-Phospho-L-serine | Procaine hydrochloride | DL-AP5 | Rapastinel Trifluoroacetate | Bupivacaine | Quininic acid

相关库: Anti-Neurodegenerative Disease Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Bioactive Compound Library

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