阿巴康唑 T7725
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 187949-02-6 | ¥11,200.00 | 询底价 |
1 mg | 187949-02-6 | ¥2,350.00 | 询底价 |
500 mg | 187949-02-6 | ¥34,800.00 | 询底价 |
10 mg | 187949-02-6 | ¥7,790.00 | 询底价 |
50 mg | 187949-02-6 | ¥13,800.00 | 询底价 |
5 mg | 187949-02-6 | ¥5,630.00 | 询底价 |
100 mg | 187949-02-6 | ¥17,500.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Albaconazole
描述: Albaconazole (W-0027)是一种小分子真菌细胞色素P450家族成员51 (fungal CYP51A1)抑制剂。它可用于治疗真菌感染、皮肤和肌肉骨骼疾病,可用于研究外阴阴道念珠菌病、Chagas病和泌尿生殖系统疾病。
体内活性: Forty participants were enrolled in this Phase I, open-label, two-sequence crossover study. Twenty participants were exposed to a single 400-mg tablet dose of albaconazole before being crossed over to a single dose of four 100-mg albaconazole capsules. The second group of 20 participants received the study products in reverse order. Blood samples were taken over 15 days post-dose to assess the plasma concentrations and pharmacokinetic parameters of albaconazole and its primary metabolite, 6-hydroxyalbaconazole. Safety was assessed throughout the study. The area under the curve (AUC) and maximum measured plasma concentration (C(max)) of the albaconazole tablet were approximately 10% and 22% lower, respectively, than for the albaconazole capsules. Statistical significance was reached for the C(max) but not for the AUC measurements (AUC(0-t) and AUC(0-inf)). Because the 90% confidence intervals based on the differences between the tablet and capsule were outside the 80%-125% range for both the C(max) and AUC, we concluded that the formulations were not bioequivalent with respect to the rate or extent of absorption. The AUC and C(max) of albaconazole after a single 400-mg oral dose administered as a tablet formulation were lower than those of a capsule formulation. Albaconazole tablets and capsules cannot, therefore, be considered bioequivalent.[1]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 55 mg/mL (127.37 mM)
关键字: Albaconazole | W0027 | UR 9825
相关产品: Salvianolic Acid C | CRTH2-IN-1 | Licopyranocoumarin | YM 511 | Ginsenoside C-K | Furafylline | 2,3-dihydrothieno-Thiadiazole Carboxylate | Demethyleneberberine | EN3356 | Resveratroloside
相关库: Drug Repurposing Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途