曲美木单抗 T77466

Product Introduction
Bioactivity


英文名: Tremelimumab

描述: Tremelimumab 是一种细胞毒性T淋巴细胞相关抗原-4（CTLA-4）阻断抗体.Tremelimumab 常与 Durvalumab 联合使用来治疗肝癌、肺癌等实体癌。

体外活性: Tremelimumab exhibits a higher binding affinity for CTLA-4-Ig compared to CD28-Ig, demonstrating specificity for cynomolgus monkeys and humans. It does not engage with human leukocyte FcγR, mitigating the risk of cytokine release syndrome. Interestingly, Tremelimumab enhances IL-2 production in a concentration-dependent manner when stimulated with staphylococcal enterotoxin A, showcasing its ability to modulate T-cell responses.[1]

存储条件: store at low temperaturestore at -20°C

关键字: CP 675206 | Tremelimumab | CP675206

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途