5-LOX抑制剂2 T77528

Product Introduction
Bioactivity


英文名: 5-LOX-IN-2

描述: 5-LOX-IN-2 是 一种 5-脂氧合酶抑制剂 (5-LOX )抑制剂，从体外实验测得的IC50 值为 0.33 μM。5-LOX-IN-2 以剂量依赖的方式抑制 5-LOX发挥作用。5-LOX-IN-2 可降低肾癌细胞的细胞活性并诱导凋亡 (apoptosis)，可用于研究癌症。

体外活性: 5-LOX-IN-2 (Compound 10b) (0-100 μM; 4 days; RCC4, RCC10, 786.0 cells) reduces the viability of renal cancer cells and is more selective for RCC4 and 786.0 cells lacking the Von Hippel-Lindau (VHL) tumor suppressor gene.[1]5-LOX-IN-2 (0-10 μM; 24 hours; RCC4, RCC10, 786.0 cells) can increase the expression of LC3B and p62, block the autophagy flux of RCC4 cells, and induce apoptosis through activation of the caspase-3 pathway. Cell death.[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (175.86 mM)


关键字: 5-LOX-IN-2 | 5LOXIN2

相关产品: Tiplaxtinin | L-685458 | PROTAC-O4I2 | Niraparib | BML-277 | RIPGBM | CMLD-2 | ZINC69391 | RSH-7 | Mitotane

相关库: Anti-Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Cancer Active Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途