化合物FL118 T77701

Product Introduction
Bioactivity


英文名: FL118

描述: FL118是一种新型存活素抑制剂，可抑制癌症干细胞样特性。FL118 是一种新型喜树碱类似物，具有抗癌活性，通过 Wnt/β-catenin 信号通路抑制上皮-间充质转化，从而抑制人乳腺癌细胞的迁移和侵袭。

体外活性: FL118 (0-200 nM; 24, 48 and 72 h) suppresses cell proliferation in ES-2 and SK-O-V3 cells. FL118 hinders cell migration in both ES-2 and SK-O-V3 cells, influencing the expression of cytoglobin (CYGB). Furthermore, FL118 inhibits the PI3K/AKT/mTOR signaling pathway and alters the expression levels of vimentin and E-cadherin in ovarian cancer cells.[1]FL118 (0-500 nM; 0-72 h) induces dephosphorylation and degradation of DDX5. Through its regulation of DDX5, FL118 influences the expression of survivin, McL-1, XIAP, cIAP2, c-Myc, and mKras.[2]FL118 (0-1 μM; 24, 48 h) exhibits significant cytotoxicity against the three tumor cell lines (A549, MDA-MB-231, and RM-1 cells). FL118 enhances PARP cleavage and triggers apoptosis in A549 cells, primarily arresting them at the G2/M phase.[3]

体内活性: FL118 (5 and 10 mg/kg; p.o.; once a week; 20 days; Fmale BALB/c nude mice) dose-dependency suppressed the growth of ES-2 tumors by upregulating the expression level of CYGB.[1]FL118 (0-1.5 mg/kg; i.p.; once every other day; five times) effectively eliminates human colon and head-and-neck tumors that acquire irinotecan or topotecan resistance.[4]FL118 (1.5 mg/kg; i.v.; once) exhibits favorable pharmacokinetics profiles.[4]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 2 mg/mL (5.10 mM)


关键字: 10,11-(Methylenedioxy)-20camptothecin | FL118

相关产品: Sepantronium bromide | LQZ-7F | LQZ-7I | Shepherdin 79-87 acetate | GDP366 | Cucurbitacin IIA

相关库: Bioactive Compounds Library Max | Inhibitor Library | Bioactive Compound Library

化合物FL118 T77701信息由TargetMol中国为您提供，如您想了解更多关于化合物FL118 T77701报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途