印枳碱 T7846
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mL | 456-12-2 | ¥150.00 | 询底价 |
500 mg | 456-12-2 | ¥247.00 | 询底价 |
100 mg | 456-12-2 | ¥119.00 | 询底价 |
1 g | 456-12-2 | ¥349.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Aegeline
描述: Aegeline 是从 Aegle marmelos 的叶子中分离出来的一种生物碱酰胺,有抗高血糖和抗血脂异常的活性。
体外活性: Aegeline enhanced GLUT4 translocation mediated 2-deoxy-glucose uptake in both time and concentration-dependent manner.?2-deoxy-glucose uptake was completely stymied by the transport inhibitors (wortmannin and genistein) in C2C12 myotubes.?Pharmacological inhibition of Akt (also known as protein kinase B) and Ras-related C3 botulinum toxin substrate 1 (Rac1) suggest that both Akt and Rac1 operate aegeline-stimulated glucose transport via distinct parallel pathways.?Moreover, aegeline activates p21 protein-activated kinase 1 (PAK1) and cofilin (an actin polymerization regulator).?Rac1 inhibitor (Rac1 inhib II) and PAK1 inhibitor (IPA-3) completely blocked aegeline-induced phosphorylation of cofilin and p21 protein-activated kinase 1 (PAK1)[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 25 mg/mL (84.07 mM)
关键字: αsyn | yeast | Inhibitor | protein | Sec22p | inhibit | toxicity | Fungal | Aegeline | SNARE
相关产品: Miconazole nitrate | APX2039 | Fludazonium chloride | Econazole nitrate | Santalol | Diallyl Trisulfide | Bupirimate | Luliconazole | Pyrimorph | Flutrimazole
相关库: Bioactive Compounds Library Max | Covalent Natural Product Library | Alkaloid Natural Product Library | Anti-Diabetic Compound Library | Traditional Chinese Medicine Monomer Library | Natural Product Library for HTS | Anti-Fungal Compound Library | Covalent Inhibitor Library | Anti-infective Natural Product Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途