7-甲氧基黄酮 T7907

Product Introduction
Bioactivity


英文名: 7-Methoxyflavone

描述: 7-Methoxyflavone 是一种分离自 Zornia brasiliensis 的化合物。它能够抑制福尔马林疼痛反应神经源期的舔爪时间 (65.6%)，有外周镇痛活性，但不影响炎症期的伤害性反映。

体内活性: The antinociceptive effect of 7-methoxyflavone (7MF) in mice using the following tests: acetic acid-induced writhing, glutamate- and formalin-induced nociception and hotplate. 7MF (30, 50, 100 and 300 μmol/kg, i.p.) reduced the number of writhes, with ID?? = 82.5 ± 11.7 μmol/kg and E max = 58.4%. 7MF treatment (100 μmol/kg, i.p.) inhibited paw-licking time in the neurogenic phase of the formalin pain response (65.6%) and did not decrease the nociceptive response in the inflammatory phase. In addition, in glutamate-induced nociception, 7MF inhibited 26% of the nociceptive answer. On the other hand, 7MF did not increase the latency time of the animals in the hotplate test. These results suggest that 7MF has peripheral antinociceptive activity

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 25 mg/mL (99.1 mM)


关键字: 7Methoxyflavone | Inhibitor | peripheral antinociceptive | 7 Methoxyflavone | inflammatory | inhibit | paw-licking time | 7-Methoxyflavone

相关库: Selected Plant-Sourced Compound Library | Bioactive Compounds Library Max | Natural Product Library for HTS | Flavonoid Natural Product Library | RO5 Drug-like Natural Product Library | NO PAINS Compound Library | Natural Product Library | Bioactive Compound Library

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