芬戈莫德 T7939
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
500 mg | 162359-55-9 | ¥1,255.00 | 询底价 |
1 mL | 162359-55-9 | ¥544.00 | 询底价 |
100 mg | 162359-55-9 | ¥457.00 | 询底价 |
1 g | 162359-55-9 | ¥1,570.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Fingolimod
描述: Fingolimod (FTY-720A) 是一种 1-磷酸鞘氨醇 (S1P) 拮抗剂,作用于 K562 和 NK 细胞,IC50为 0.033 nM。它还是pak1激活剂和免疫抑制剂。
细胞实验: Sciatic nerve crush was performed in wildtype C57BL/6, in immunodeficient Rag1 (-/-) and Foxn1 (-/-) mice.?Analyses were based on walking track analysis and electrophysiology, histology, and cAMP formation.?Quantification of different LPA species was performed by liquid chromatography coupled to tandem mass spectrometry.?Furthermore, functional consequences of autotaxin inhibition by the specific inhibitor PF-8380 and the impact of fingolimod on early cytokine release in the injured sciatic nerve were investigated[1].
体外活性: Fingolimod通过抑制溶血磷脂酶自噬毒素来降低LPA合成。Fingolimod治疗与轴突cAMP的显著增加相关,这对于轴突生长至关重要。此外,Fingolimod显著减少了受伤神经中的LPA水平。PF-8380治疗与髓鞘厚度的改善相关[1]。
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: Methanol : 30 mg/mL (97.57 mM)
Ethanol : 7.69 mg/mL (25.01 mM)
DMSO : 66.67 mg/mL (216.83 mM)
关键字: LPL Receptor | Inhibitor | Fingolimod | inhibit | FTY720 | PAK | FTY 720 | Lysophospholipid Receptor | p21 activated kinases
相关产品: Phorbol 12-myristate 13-acetate | Ozanimod | Amiselimod hydrochloride | Ponesimod | SphK1&2-IN-1 | SK1-IN-1 | SKI-178 | MP-A08 | PF429242 dihydrochloride | CYM-5541
相关库: Drug Repurposing Compound Library | FDA-Approved Kinase Inhibitor Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | Inhibitor Library | Kinase Inhibitor Library | GPCR Compound Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Approved Drug Library | EMA Approved Drug Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途