癸氟奋乃静 T7943

Product Introduction
Bioactivity


英文名: Fluphenazine decanoate

描述: Fluphenazine decanoate 是一种高度连续的多巴胺 D2受体阻滞剂，是一种长效吩噻嗪抗精神病药，用于精神分裂症的研究。

体内活性: Six female Persian onagers (Equus hemionus onager) were treated with fluphenazine decanoate (FD;?0.1?mg/kg IM) or saline control in a random crossover design study.?Urinary cortisol, progesterone, estrogen metabolites and behavior were monitored, and follicular dynamics were examined using ultrasonography until ovulation.?Onagers demonstrated significantly lower cortisol concentrations (P?=?0.03) when treated with FD (6.61?±?3.26?ng/mg creatinine) compared to saline (9.73?±?3.19?ng/mg creatinine).?Overall, there were no differences in peak estrogen (P?=?0.51) or progesterone (P?=?0.38) concentrations between the two groups, and all animals ovulated within the expected time frame following FD treatment.?However, some onagers exhibited only minor reductions in cortisol secretion and one treated female demonstrated a suppressed luteal progesterone peak, indicating a possible reproductive cost to FD administration[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 125 mg/mL (211.23 mM)


关键字: hypothalamic tyrosine hydroxylase levels | gonadotropin suppression | phenothiazine | T. gondii | Inhibitor | reproductive | mouth movements | hyperprolactinemia | Fluphenazine decanoate | neuroleptic | inhibit | Dopamine Receptor | dopamine-D2 | human tardive dyskinesia | antifertility | serum prolactin | schizophrenia | long-acting | jaw tremor | vacuous chewing mouth movement

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相关库: Drug Repurposing Compound Library | Anti-Neurodegenerative Disease Compound Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | CNS-Penetrant Compound Library | GPCR Compound Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Approved Drug Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途