甲基橙皮甙查尔酮 T7980
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mL | 24292-52-2 | ¥460.00 | 询底价 |
100 mg | 24292-52-2 | ¥197.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Hesperidin methylchalcone
描述: Hesperidin methylchalcone 抑制氧化应激,细胞因子产生和NF-κB 活化。它能够抑制炎症和疼痛,具有血管保护作用。
体内活性: Hesperidin methylchalcone (HMC) in a mouse model of gout arthritis induced by intra-articular injection of MSU (100 μg/10 μL).?Orally given HMC (3-30 mg/kg, 100 μL) reduced in a dose-dependent manner the MSU-induced hyperalgesia (44%, p 0.05), edema (54%, p 0.05), and leukocyte infiltration (70%, p 0.05).?HMC (30 mg/kg) inhibited MSU-induced infiltration of LysM-eGFP+ cells (81%, p 0.05), synovitis (76%, p 0.05), and oxidative stress (increased GSH, FRAP, and ABTS by 62, 78, and 73%, respectively;?reduced O2- and NO by 89 and 48%, p 0.05) and modulated cytokine production (reduced IL-1β, TNF-α, IL-6, and IL-10 by 35, 72, 37, and 46%, respectively, and increased TGF-β by 90%, p 0.05).?HMC also inhibited MSU-induced NF-κB activation (41%, p 0.05), gp91phox (66%, p 0.05) and NLRP3 inflammasome components mRNA expression in vivo (72, 77, 71, and 73% for NLRP3, ASC, pro-caspase-1, and pro-IL-1 β, respectively, p 0.05), and induced Nrf2/HO-1 mRNA expression (3.9- and 5.1-fold increase, respectively, p 0.05).?HMC (30, 100, and 300 μM) did not inhibit IL-1β secretion by macrophages primed by LPS and challenged with MSU (450 μg/mL), demonstrating that the anti-inflammatory effect of HMC in gout arthritis depends on inhibiting NF-κB but not on direct inhibition of inflammasome[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 10 mg/mL (16.1 mM)
关键字: Inhibitor | Nuclear factor-kappaB | inhibit | Nuclear factor-κB | NF-κB | Hesperidin methylchalcone
相关产品: Physalin A | Muscone | CAFESTOL | Sodium Houttuyfonate | Kushenol C | Siegeskaurolic acid | 2-Methoxystypandrone | Valencene | Cyclo(his-pro) | Barlerin
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途