岩藻甾醇 T8184

Product Introduction
Bioactivity


英文名: Fucosterol

描述: Fucosterol 是从藻类、海藻或硅藻中分离的一种甾醇，具有抗氧化、抗脂肪、降低血液胆固醇、抗糖尿病和抗癌活性。它通过抑制 PPARα和C/EBPα的表达调控脂肪生成，可用于抗肥胖试剂开发研究。

细胞实验: Cell Line: 3T3-L1 adipocytes. Concentration: 0 μM; 25 μM; 50 μM. Incubation Time: 7 days [1]

体外活性: Fucosterol (0-50 μM; 7 days) suppresses the expression of PPARα and C/EBPα when compared to fully differentiated control adipocytes [1]. Fucosterol shows cytotoxicity against T47D and HT29 cell lines (IC50s: 27.94 and 70.41 μg/ml) [3]. Fucosterol decreases the proliferation of HEK293, MCF-7, and SiHa cells (IC50s: 185.4, 43.3, and 34.0 μg/ml) [4].

体内活性: Fucosterol（p.o.；30mg/kg）显著降低血清葡萄糖浓度，并展现出对晶状体中山梨醇积累的抑制作用[2]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : 16.67 mg/mL (4.39 mM)


关键字: poly ADP ribose polymerase | Inhibitor | inhibit | Endogenous Metabolite | PARP | Fucosterol

相关产品: PARP1-IN-15 | WAY-620473 | PARP7-IN-15 | Benzamide | PARP1-IN-17 | Niraparib tosylate | Hellebrigenin | MK-4827 Racemate | PARP1-IN-5 dihydrochloride  | Pamiparib

相关库: Marine Natural Product Library | Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library | Oxidation-Reduction Compound Library | Tobacco Monomer Library | Human Metabolite Library | Anti-Diabetic Compound Library | Anti-Cancer Active Compound Library | Traditional Chinese Medicine Monomer Library | Food as Medicine Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途