α-侧柏酮 T8193

Product Introduction
Bioactivity


英文名: α-Thujone

描述: α-Thujone 是一种从西方金钟柏精油中分离出来的单萜，可穿透血脑屏障。它是 GABAA 受体的可逆调节剂，在抑制 GABA 诱导的电流时，它的 IC50为 21 μM。它诱导 ROS 依赖性细胞毒性，还诱导细胞凋亡和自噬。它具有抗伤害，抗肿瘤、杀虫和驱虫活性。

体外活性: In in-vivo one-trial passive avoidance paradigm show that thujone (1.25mg/kg, i.p.) significantly impaired nicotine-induced enhancement of learning and memory in Wistar rats[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 4.4 mg/mL (28.9 mM)


关键字: pro-apoptotic | anti-invasive | α Thujone | Monoterpene | oxidative | antinociceptive | ALPHA-THUJONE | Gamma-aminobutyric acid Receptor | Apoptosis | Inhibitor | BBB | γ-Aminobutyric acid Receptor | inhibit | Reactive Oxygen Species | Autophagy | GABA Receptor | ROS | Parasite | αThujone | anthelmintic | α-Thujone | anti-tumor | a-Thujone | insecticidal | stress

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相关库: Anti-Neurodegenerative Disease Compound Library | Membrane Protein-targeted Compound Library | Anti-Ovarian Cancer Compound Library | Inhibitor Library | Anti-Parasitic Compound Library | Traditional Chinese Medicine Monomer Library | Anti-Cancer Active Compound Library | Anti-Fibrosis Compound Library | Antiparasitic Natural Product Library | RO5 Drug-like Natural Product Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途