化合物T-1101 tosylate T8216

Product Introduction
Bioactivity


英文名: T-1101 tosylate

描述: T-1101 tosylate (TAI-95 tosylate) 是一种具有抗肿瘤活性的 Hec1/Nek2抑制剂。

动物实验: SCID mice bearing human Huh-7, BT-474, MCF-7, and MDA-MB-231 xenografts. Dosage:25 mg/kg, 50 mg/kg. Oral administration; twice per day; 28 days

体外活性: T-1101 has good oral absorption, along with potent in?vitro antiproliferative activity (IC50: 14.8-21.5?nM).

体内活性: T-1101 tosylate can achieve high concentrations in Huh-7 and MDA-MB-231 tumor tissues, and showed promise in antitumor activity in mice bearing human tumor xenografts of liver cancer (Huh-7).

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 11 mg/mL (16.52 mM)


关键字: TAI95 | T1101 Tosylate | T1101 tosylate | T-1101 Tosylate | TAI95 Tosylate | TAI-95 | T 1101 Tosylate | T1101 | Apoptosis | Inhibitor | inhibit | T 1101 | T-1101 | TAI-95 Tosylate | PPI | TAI 95 | Hec1/Nek2 | TAI 95 Tosylate | T 1101 tosylate

相关产品: Pinoresinol | β-Carotene | ONC212 | LRRK2-IN-1 | Azoramide | BMS-833923 | ICG-001 | Demethoxycurcumin | Dioscin | AZD-3463

相关库: Drug Repurposing Compound Library | Anti-Cancer Drug Library | Microtubule-Targeted Compound Library | Clinical Compound Library | Inhibitor Library | Anti-Cancer Clinical Compound Library | Cytoskeletal Signaling Pathway Compound Library | Anti-Cancer Active Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途