福沙那伟钙 T8238

Product Introduction
Bioactivity


英文名: Fosamprenavir Calcium Salt

描述: Fosamprenavir Calcium Salt (GW433908G) 是抗逆转录病毒蛋白酶抑制剂 Amprenavir 的磷酸酯前药，具有改善的溶解性和抗HIV 感染作用。

动物实验: DATS was given orally (6 micromoL, thrice weekly) to male athymic mice s.c. implanted with PC-3 cells. Tumor sections from control and DATS-treated mice were examined for apoptotic bodies by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assay. Protein levels of apoptosis and cell cycle regulating proteins in tumor tissues of control and DATS-treated mice were determined by immunoblotting. The effect of DATS treatment on in vivo angiogenesis was determined by immunohistochemical analysis of CD31 in tumors[1].

体内活性: Oral gavage of DATS significantly retarded growth of PC-3 xenografts in athymic mice without causing weight loss. For instance, 20 days after starting therapy, the average tumor volume in control mice was approximately 3-fold higher compared with DATS-treated mice. Tumors from DATS-treated mice exhibited a markedly higher count of apoptotic bodies compared with control tumors. Consistent with the results in cultured PC-3 cells, the DATS-mediated suppression of PC-3 xenograft growth correlated with induction of proapoptotic proteins Bax and Bak. Although DATS treatment inhibited migration of cultured PC-3 cells in association with down-regulation of vascular endothelial growth factor receptor-2 protein, formation of new blood vessels was comparable in tumors of control and DATS-treated mice as judged by CD31 immunostaining[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 1.8 mg/mL (2.89 mM)
H2O : 0.25 mg/mL (0.40 mM)


关键字: Human immunodeficiency virus | HIV | Inhibitor | Fosamprenavir Calcium Salt | Diallyl | inhibit

相关产品: (Rac)-Telinavir | LJ-001 | Didanosine | HIV-1 protease-IN-12 | BI 224436 | Emtricitabine | PKF050-638 | Tenofovir alafenamide hemifumarate | Ganoderic acid C1 | Abacavir sulfate

相关库: FDA-Approved Drug Library | Drug Repurposing Compound Library | Approved Drug Library | FDA-Approved & Pharmacopeia Drug Library | Clinical Compound Library | Bioactive Compounds Library Max | Inhibitor Library | EMA Approved Drug Library | Anti-Viral Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途