表小檗碱氯化物 T8306

Product Introduction
Bioactivity


英文名: Epiberberine chloride

描述: Epiberberine chloride (Epiberberine (chloride)) 是一种从黄连中得到的生物碱，是一种AChE 和BChE 抑制剂，和非竞争性的BACE1抑制剂。它具有抗氧化作用，能够清除 ONOO-，可用于研究阿尔滋海默症和糖尿病。

体外活性: Epiberberine chloride has antioxidant activity, with peroxynitrite ONOO- scavenging effect (IC50, 16.83 μM), and may protect against Alzheimer disease[1]. Epiberberine (0, 12.5, 25, or 50 μM) dose-dependently inhibits cellular triglyceride accumulation in 3T3-L1 adipocytes (IC50: 52.8 μM). Epiberberine (12.5-50 μM) suppresses the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways in the early stage of 3T3-L1 adipocyte differentiation [2]. Epiberberine (0.2, 1, 5 μg/mL) inhibits glucose uptake in HepG2 cells in a concentration-dependent manner [3].

体内活性: Body weight, food consumption, water intake, and urinary output of KK-Ay mice were reduced after being treated with Epiberberine (225 mg/kg, p.o. daily for 40 days).

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 7.4 mg/mL (19.9 mM)


关键字: Reactive Oxygen Species | Epiberberine | Epiberberine chloride | Cholinesterase (ChE) | inhibit | β-Secretase | Epiberberine Chloride | Inhibitor | BACE | Beta-secretase

相关产品: β-Elemonic Acid | CP-312 | Tempo | Berberine chloride | Isobavachalcone | Cobalt protoporphyrin IX | 2-Methoxyestradiol | Nisoldipine | Berberine | N-Acetyl-D-cysteine

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途