加替沙星盐酸盐 T8384

Product Introduction
Bioactivity


英文名: Gatifloxacin hydrochloride

描述: Gatifloxacin hydrochloride (AM-1155 hydrochloride) 是一种氟喹诺酮类抗生素，有广谱抗菌活性。它可抑制大肠杆菌 DNA 解旋酶 (IC50=0.109 μg/ml)和细菌 II 型拓扑异构酶(IC50=13.8 μg/ml) 。它在动物模型中，可研究细菌性结膜炎。

动物实验: Heptanol-induced corneal ulcers in New Zealand White rabbits (n = 41; 8 females/group) were inoculated with 10(6) CFU of Pseudomonas aeruginosa. Gatifloxacin 0.3% dosing varied among 4 groups with frequencies of 16-48 doses/day (days 1-2), 3-16 doses/day (days 3-7), and maintenance dosing of 3-4 doses/day (days 8-22). Ciprofloxacin 0.3% was administered as labeled for corneal ulcers, with 44 doses on day 1, 16 doses on day 2, and 4 doses/day on days 3-21[1]

体内活性: All eyes showed evidence of infection by 48 hours postinoculation with 36 of 41 eyes (87.8%) exhibiting moderate-to-severe keratitis. All eyes exhibited corneal healing by day 15, with no significant differences among groups. Three of 4 groups receiving gatifloxacin tended to have smaller fluorescein retention area scores than did the ciprofloxacin group. No eyes tested positive for Pseudomonas at the end of the study. No corneal precipitates were found following as many as 48 doses/day of gatifloxacin[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 10 mg/mL (24.28 mM)
DMSO : 4.12 mg/mL (10 mM)


关键字: Antibiotic | AM1155 | BMS-206584 | E. coli,?Pseudomonas aeruginosa,?Micrococcus luteus | Gatifloxacin | PD-135432 | BMS 206584 | conjunctivitis | N. brasiliensis | actinomycetoma | Gatifloxacin hydrochloride | Inhibitor | S. aureus | Bacterial | inhibit | hypoglycemia | Topoisomerase | AM 1155 | Gatifloxacin Hydrochloride | diabetic | PD135432 | hyperglycemia | PD 135432 | BMS206584 | AM-1155

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相关库: Drug Repurposing Compound Library | Approved Drug Library | Drug-induced Liver Injury (DILI) Compound Library | Inhibitor Library | DNA Damage & Repair Compound Library | Anti-Bacterial Compound Library | Anti-Infection Compound Library | Bioactive Compound Library | Natural Product Library | Anti-infective Natural Product Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途