化合物Ro 8-4304 T8447

Product Introduction
Bioactivity


英文名: Ro 8-4304

描述: Ro 8-4304 Hydrochloride 是 NMDA 受体的拮抗剂，IC50 为 0.4 μM。

体外活性: Ro 8-4304 is a voltage-independent, non-competitive antagonist of NMDA receptors in rat cultured cortical neurones and exhibits a state-dependent mode of action similar to that described for ifenprodil.?The apparent affinity of Ro 8-4304 for the NMDA receptor increased in an NMDA concentration-dependent manner so that Ro 8-4304 inhibited 10 and 100 microM NMDA responses with IC50s of 2.3 and 0.36 microM, respectively.?Currents elicited by 1 microM NMDA were slightly potentiated in the presence of 10 microM Ro 8-4304, and Ro 8-4304 binding slowed the rate of glutamate dissociation from NMDA receptors

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Ro 8-4304 | Ro 84304 | Ro 8 4304

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途