化合物Tenovin-6 Hydrochloride T8480

Product Introduction
Bioactivity


英文名: Tenovin-6 Hydrochloride

描述: Tenovin-6 Hydrochloride 是 Tenovin-1 的类似物，能抑制二氢乳清酸脱氢酶。它是一种 p53转录活性的激活剂，抑制纯化人 SIRT1、SIRT2 和 SIRT3 蛋白脱乙酰酶活性，IC50分别为 21 μM、10 μM 和 67 μM。

体外活性: Inhibition of SIRT1/2 by Tenovin-6 induced apoptosis in UM cells by activating the expression of tumor suppressor genes such as p53 and elevating reactive oxygen species (ROS).?Tenovin-6 inhibited the growth of UM cells.?Tenovin-6 and vinblastine was synergistic in inducing apoptosis of UM cell line 92.1 and Mel 270.?Furthermore, Tenovin-6 eliminated cancer stem cells in 92.1 and Mel 270 cells.?In conclusion, our findings suggest that Tenovin-6 may be a promising agent to kill UM bulk tumor cells and CSCs[1].tenovin-6 increases microtubule-associated protein 1 light chain 3 (LC3-II) level in diverse cell types in a time- and dose-dependent manner. Mechanistically, the increase of LC3-II by tenovin-6 is caused by inhibition of the classical autophagy pathway via impairing lysosomal function without affecting the fusion between autophagosomes and lysosomes.tenovin-6 activation of p53 is cell type dependent, and tenovin-6 inhibition of autophagy is not dependent on its regulatory functions on p53 and SIRT1[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 45 mg/mL (91.63 mM)


关键字: acetylation | Dihydroorotate Dehydrogenase | protein-deacetylating | Tenovin 6 Hydrochloride | Autophagy | Sirtuin | DHODH | Tenovin 6 | Inhibitor | degradation | Tenovin6 | Tenovin6 Hydrochloride | inhibit | Tenovin-6 Hydrochloride | MDM2 | MDM-2/p53 | Tenovin-6

相关产品: Tiazofurin | Prunetin | Dicoumarol | BRD9185 | BAY-1436032 | Methotrexate disodium | A939572 | DHODH-IN-14 | Ethionamide | Atovaquone

相关库: Glycometabolism Compound Library | Anti-Cancer Metabolism Compound Library | Bioactive Compounds Library Max | Anti-Lung Cancer Compound Library | Inhibitor Library | Anti-Diabetic Compound Library | Apoptosis Compound Library | PPI Inhibitor Library | Metabolism Compound Library | Chromatin Modification Compound Library

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