化合物THIQ T8485

Product Introduction
Bioactivity


英文名: THIQ

描述: THIQ 是一种选择性黑皮质素 4 受体 (MC4R) 激动剂，对 hMC4R 和 rMC4R 的 IC50 分别为 1.2 和 0.6 nM。

体外活性: THIQ,?a small molecule agonist of the MC4R, on the cell surface expression and signaling of ten intracellularly retained MC4R mutants using different cell lines.?THIQ increased the cell surface expression of three mutants (N62S, C84R, and C271Y) and two of them (N62S and C84R) had increased signaling in HEK293 cells.THIQ increased the signaling of two other mutants (P78L and P260Q) without increasing their cell surface expression in HEK293 cells.?In neuronal cells, THIQ exhibited a more potent effect, correcting the cell surface expression and signaling of seven mutants (N62S, I69R, P78L, C84R, W174C, P260Q, and C271Y).

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 245 mg/mL(415.84 mM)


关键字: mutant | MC Receptor | inhibit | melanocortin | affinity | activity | erectile | selective | eliciting | Melanocortin Receptor | THIQ | Inhibitor

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相关库: Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | GPCR Compound Library | Anti-Obesity Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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