化合物MAZ51 T8496

Product Introduction
Bioactivity


英文名: MAZ51

描述: MAZ51 是一种 VEGFR-3酪氨酸激酶的选择性抑制剂。它抑制 VEGF-C 诱导的 VEGFR-3 激活，而没有阻断 VEGF-C 介导的 VEGFR2 刺激。它阻止增殖并诱导多种肿瘤细胞凋亡，具有抗肿瘤活性。

体外活性: MAZ51能够阻断表达VEGFR-3的人类内皮细胞的增殖，并且较低效地诱导其凋亡。MAZ51还抑制了多种非VEGFR-3表达肿瘤细胞系的增殖，并诱导其凋亡[1]。

体内活性: In vivo, MAZ51 significantly inhibits the growth of rat mammary carcinomas.?These data establish MAZ51 as a compound with antitumor properties that inhibits tumor growth directly and also indirectly by interfering with tumor-host interactions[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 3.33 mg/mL(10.59 mM)


关键字: EGFR | Apoptosis | growth | phosphorylation | Inhibitor | inhibit | PDGFRβ | MAZ 51 | MAZ51 | tumor | VEGF-D | indolinone | MAZ-51 | VEGFR | IGF-1R | VEGF-C | Vascular endothelial growth factor receptor | ligand-induced | proliferation

相关产品: RUNX-IN-2 | Glaucocalyxin A | Perifosine | (E)-Cardamonin | (E/Z)-BCI | Topotecan hydrochloride | MT 63-78 | Gliotoxin | Avobenzone | HBDDE

相关库: Anti-Prostate Cancer Compound Library | Angiogenesis related Compound Library | Bioactive Compounds Library Max | Anti-Ovarian Cancer Compound Library | Inhibitor Library | Kinase Inhibitor Library | Anti-Cancer Active Compound Library | Tyrosine Kinase Inhibitor Library | Anti-Fibrosis Compound Library | Stem Cell Differentiation Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途