化合物eCF506 T8499

Product Introduction
Bioactivity


英文名: eCF506

描述: eCF506 是一种高效的、口服具有活力的非受体酪氨酸激酶Src 抑制剂，其IC50<0.5 nM。

体内活性: eCF506, the first small molecule with subnanomolar IC50 for SRC that requires 3 orders of magnitude greater concentration to inhibit ABL.?eCF506 exhibits excellent water solubility, an optimal DMPK profile and oral bioavailability, halts SRC-associated neuromast migration in zebrafish embryos without inducing life-threatening heart defects, and inhibits SRC phosphorylation in tumor xenografts in mice.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 62.5 mg/mL (122.40 mM)


关键字: eCF-506 | eCF506 | Inhibitor | Src | eCF 506 | inhibit

相关产品: SU6656 | Beta-Hydroxyisovalerylshikonin | GW297361 | 1-Naphthyl PP1 | Tofacitinib | TPX-0046 | CSF1R-IN-2 | 1-Naphthyl PP1 hydrochloride | squarunkinA | OSI-930

相关库: Anti-Cancer Metabolism Compound Library | Angiogenesis related Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Kinase Inhibitor Library | Inhibitor Library | Tyrosine Kinase Inhibitor Library | Orally Active Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途