化合物TM38837 T8511

Product Introduction
Bioactivity


英文名: TM38837

描述: TM38837 是外周选择性大麻素受体1型受体拮抗剂。它减少精神病副作用的倾向。它对大脑的渗透率有限，以降低或防止 CNS 不良反应，并保留潜在的抗肥胖作用。

体内活性: TM38837, a novel, largely peripherally restricted CB1 antagonist, in terms of fear-promoting consequences of systemic vs. intracerebral injections.?Different groups of male C57BL/6 N mice underwent auditory fear conditioning, followed by re-exposure to the tone.?Mice were treated per os (p.o.) with TM38837 (10, 30, or 100 mg/kg), rimonabant (10 mg/kg;?a brain penetrating CB1 antagonist/inverse agonist which served as a positive control), or vehicle, 2 h prior the tone presentation.?Only the high dose of TM38837 (100 mg/kg) induced a significant increase in freezing behavior, similar to that induced by rimonabant (10 mg/kg) (p
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 40 mg/mL (64.77 mM)


关键字: peripheral | Cannabinoid Receptor | CB1 | TM-38837 | antiobesity | TM 38837 | TM38837 | inhibit | fat | Inhibitor | metabolic | fear

相关产品: (R)-Monlunabant | (±)-Ibipinabant | Rimonabant | ML-184 | 6-Iodopravadoline | Tetrahydromagnolol | OMDM-5 | EHP-101 | CB1 antagonist 2 | Pregnenolone

相关库: Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Inhibitor Library | GPCR Compound Library | Anti-Diabetic Compound Library | Anti-Obesity Compound Library | Anti-Fibrosis Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途