没药醇 T8516
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mL | 23089-26-1 | ¥195.00 | 询底价 |
100 mg | 23089-26-1 | ¥640.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Levomenol
描述: Levomenol ((-)-α-BISABOLOL) 是一种单环倍半萜醇,具有有神经保护、抗氧化、抗炎和抗凋亡的作用。它可减轻三叉神经性疼痛啮齿动物模型的伤害性行为和中枢敏感性。它通过减少小鼠永久性局灶性脑缺血诱导的促炎标志物,防止神经元损伤和记忆缺陷。
体外活性: (-)-α-bisabolol was able to activate a programmed cell death process in the promastigote stage of the parasite.?It causes phosphatidylserine externalization and membrane damage.?Moreover, it decreases the mitochondrial membrane potential and total ATP levels.?These results highlight the potential use of (-)-α-bisabolol against both L. amazonensis and L. infantum, and further studies should be undertaken to establish it as novel leishmanicidal therapeutic agents[1].
体内活性: Levomenol inhibits the growth of L. amazonensis promastigotes and amastigotes (IC50s = 8.07 and 4.29 μg/ml, respectively). It also reduces the growth of L. infantum and L. donovani amastigotes (IC50s = 56.9 and 39.4 μM, respectively) with a cytotoxic concentration (CC50) value of greater than 1,000 μM in L929 cells[2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 22.5 mg/mL (101.18 mM)
关键字: unsaturated sesquiterpene alcohol | antioxidant | inhibit | anti-inflammatory | Inhibitor | α-BISABOLOL | oral | Levomenol | neuroprotective effects | Apoptosis | a-BISABOLOL | alpha-BISABOLOL
相关库: Antioxidant Compound Library | Drug Repurposing Compound Library | Terpene Natural Product Library | Bioactive Compounds Library Max | Ferroptosis Compound Library | Human Endogenous Metabolite Compound Library Plus | Traditional Chinese Medicine Monomer Library | NO PAINS Compound Library | Bioactive Compound Library | Natural Product Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途