化合物Apcin T8561
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mg | 300815-04-7 | ¥346.00 | 询底价 |
1 mL | 300815-04-7 | ¥879.00 | 询底价 |
2 mg | 300815-04-7 | ¥490.00 | 询底价 |
25 mg | 300815-04-7 | ¥2,610.00 | 询底价 |
5 mg | 300815-04-7 | ¥797.00 | 询底价 |
50 mg | 300815-04-7 | ¥3,880.00 | 询底价 |
100 mg | 300815-04-7 | ¥5,580.00 | 询底价 |
10 mg | 300815-04-7 | ¥1,290.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Apcin
描述: Apcin 是后期促进复合物/环体 (APC/C(Cdc20)) E3 连接酶活性的有效竞争性抑制剂,可通过与 Cdc20 结合并阻止底物识别竞争性地抑制 APC/C 依赖性泛素化。它占据 WD40 结构域侧面的 D-box 结合口袋,并可以延长有丝分裂。它通过阻断有丝分裂退出并通过共同添加 Ts-Arg-OMe 协同放大而起作用。
体外活性: apcin as a small molecule ligand of Cdc20 that inhibits APC/CCdc20 and prolongs mitosis.?apcin paradoxically shortens mitosis when SAC activity is high.?These opposing effects of apcin arise from targeting of a common binding site in Cdc20 required for both substrate ubiquitination and MCC-dependent APC/C inhibition.?Furthermore, apcin cooperates with p31comet to relieve MCC-dependent inhibition of APC/C.?Apcin therefore causes either net APC/C inhibition, prolonging mitosis when SAC activity is low, or net APC/C activation, shortening mitosis when SAC activity is high, demonstrating that a small molecule can produce opposing biological effects depending on regulatory context.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 240 mg/mL (547.13 mM)
关键字: ligase | pocket | anaphase-promoting | recognition | complex | Inhibitor | Cdc20 | Anaphase promoting complex | cyclosome | ubiquitylation | inhibit | mitosis | WD40-domain | Apcin | APC/C | APC
相关产品: TASIN-1 | CFM 4 | TASIN-1 Hydrochloride | TAME | TAME hydrochloride | Activated Protein C (390-404), human acetate | Apcin A HCL
相关库: Anti-Aging Compound Library | Cell Cycle Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | NO PAINS Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途