化合物PF-06446846 T8645

Product Introduction
Bioactivity


英文名: PF-06446846

描述: PF-06446846 是口服有活性的 PCSK9抑制剂。它能够在密码子区域附近阻断 80S ribosome，选择性地直接抑制 PCSK9 的翻译。

体内活性: PF-06446846 reduces plasma PCSK9 and total cholesterol levels in rats following oral dosing.?PF-06446846 is highly selective for the inhibition of PCSK9 translation.?The mechanism of action employed by PF-06446846 reveals a previously unexpected tunability of the human ribosome that allows small molecules to specifically block translation of individual transcripts.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 4.34 mg/mL (10 mM)


关键字: Threonine proteases | PF 06446846 | PF-06446846 | Inhibitor | 80S ribosome | Selective | Ser/Thr Protease | Serine proteases | Rat bone marrow | Huh7 | inhibit | PF06446846 | Serine endopeptidases

相关库: Bioactive Compounds Library Max | Inhibitor Library | Orally Active Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途