化合物BCH001 T8647

Product Introduction
Bioactivity


英文名: BCH001

描述: BCH001 是喹啉衍生物，是一种选择性PAPD5抑制剂。它可以恢复先天性角化病诱导的多能干细胞中的端粒酶活性和端粒长度。它对聚 (A)-特异性核糖核酸酶或几种其他多核苷酸聚合酶均无抑制作用。它可用于调控衰老。

体内活性: BCH001, a specific PAPD5 inhibitor that restored telomerase activity and telomere length in DC patient induced pluripotent stem cells.?When human blood stem cells engineered to carry DC-causing PARN mutations were xenotransplanted into immunodeficient mice, oral treatment with a repurposed PAPD5 inhibitor, the dihydroquinolizinone RG7834, rescued TERC 3' end maturation and telomere length.?

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 84 mg/mL (199.84 mM)


关键字: PARN | dyskeratosis | telomerase | stem | polynucleotide | TERC | rPAPD5 | ncRNA | BCH-001 | polymerases | oligo-adenylation | congenita | inhibit | PAPD5 | pluripotent | BCH 001 | iPSC | DNA/RNA Synthesis | BCH001 | telomere | Inhibitor

相关产品: BMH-21 | TH588 | Procaine | Procarbazine hydrochloride | 1-Decarboxy-3-oxo-ceanothic acid | RG7800 tetrahydrochloride | 2-Aminopurine | DMT-dG(ib) Phosphoramidite | ISOPIMPINELLIN | IMT1B

相关库: Cell Cycle Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | DNA Damage & Repair Compound Library | NO PAINS Compound Library | Bioactive Compound Library

化合物BCH001 T8647信息由TargetMol中国为您提供，如您想了解更多关于化合物BCH001 T8647报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途