化合物CAY10404 T8656

Product Introduction
Bioactivity


英文名: CAY10404

描述: CAY10404 (3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T) 是一种有效且高度选择性的 COX-2 和 COX-1 抑制剂。 它还是 PKB/Akt 和 MAPK 信号通路的有效抑制剂，可诱导 NSC-LC 细胞凋亡，具有镇痛、抗炎和抗癌活性。

细胞实验: To measure the effects of CAY10404 on proliferation of NSCLC cells, 3 x 10(3) cells/well were plated in 96-well plates and allowed to adhere overnight at 37 degrees C. After treatment with CAY10404 for 3 days, cell proliferation was measured by the 3- (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. In the H460 NSCLC cells, evidence of apoptosis was sought using the terminal deoxynucleotidyl transferase deoxyuridine triphosphate (dUTP) nick end labelling (TUNEL) assay and western blot analysis[1].

体外活性: Treatment with CAY10404 in the range of 10-100 microM caused dose-dependent growth inhibition, with an average 50% inhibitory concentration (IC(50)) of 60-100 micromol/L, depending on the cell line.?Western blot analysis of CAY10404-treated cells showed cleavage of poly (ADP-ribose) polymerase (PARP) and procaspase-3, signifying caspase activity and apoptotic cell death.?CAY10404 treatment inhibited the phosphorylation of Akt, glycogen synthase kinase-3beta and extracellular signal-regulated kinases 1/2 in H460 and H358 cells[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 10 mg/mL (27.22 mM)


关键字: Bcl-XL | cancer | COX | anti-inflammatory | Bcl-2 | Apoptosis | Akt | H-1703 | Cyclooxygenase | CAY-10404 | NSCLC | H-358 | inhibit | cell | pGSK-3β | CAY10404 | H-460 | analgesic | MAPK | cyclooxygenase-2 | lung | anti-cancer | Inhibitor | Non-small | CAY 10404 | Protein kinase B | pAkt | PKB

相关产品: Jaceosidin | Chelidonine | icFSP1 | Staurosporine | Nirogacestat | Anticancer agent 105 | BTR-1 | LY-411575 | MARK4 inhibitor 1 | Geniposidic Acid

相关库: Anti-Aging Compound Library | PI3K-AKT-mTOR Compound Library | Anti-Prostate Cancer Compound Library | Anti-Lung Cancer Compound Library | Inhibitor Library | Kinase Inhibitor Library | Anti-Cancer Active Compound Library | Metabolism Compound Library | Stem Cell Differentiation Compound Library | Glycolysis Compound Library

化合物CAY10404 T8656信息由TargetMol中国为您提供，如您想了解更多关于化合物CAY10404 T8656报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途