化合物KYP-2047 T8657

Product Introduction
Bioactivity


英文名: KYP-2047

描述: KYP-2047 是一种非常有效的选择性脯氨酰寡肽酶 (POP) 抑制剂。

体外活性: In cell lines, oxidative stress induced a robust aggregation of α-synuclein,and low concentrations of KYP-2047 significantly reduced the number of cells with α-synuclein inclusions while abolishing the colocalization of α-synuclein and PREP. KYP-2047 significantly reduced the amount of aggregated α-synuclein,and it had beneficial effects on cell viability.?In the transgenic mice, a 5-day treatment with the PREP inhibitor reduced the amount of α-synuclein immunoreactivity and soluble α-synuclein protein in the brain[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 25 mg/mL (73.65 mM)


关键字: eNOS | inhibit | POP | Neurotensin | Angiopoietins | MDM-2/p53 | KYP 2047 | prolyl oligopeptidase | Glioblastoma | KYP-2047 | VEGF | KYP2047 | Prolyl Endopeptidase (PREP) | Inhibitor | U-87 cell | Apoptosis

相关库: Bioactive Compounds Library Max | Inhibitor Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途