化合物JNJ-5207852 dihydrochloride T8822
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
2 mg | 1782228-76-5 | ¥698.00 | 询底价 |
50 mg | 1782228-76-5 | ¥4,970.00 | 询底价 |
100 mg | 1782228-76-5 | ¥7,230.00 | 询底价 |
1 mg | 1782228-76-5 | ¥482.00 | 询底价 |
500 mg | 1782228-76-5 | ¥14,300.00 | 询底价 |
5 mg | 1782228-76-5 | ¥997.00 | 询底价 |
25 mg | 1782228-76-5 | ¥3,520.00 | 询底价 |
10 mg | 1782228-76-5 | ¥1,750.00 | 询底价 |
Product Introduction
Bioactivity
英文名: JNJ-5207852 dihydrochloride
描述: JNJ-5207852 dihydrochloride 是一种新型的非咪唑组胺 H3 受体拮抗剂,对大鼠和人类 H3受体的 pKi 值分别为 8.9 和 9.24。
体内活性: JNJ-5207852 is a potent dibasic amine antagonist that binds potently to rat H3 receptors (Ki=1.2?nm), and has good brain penetration. In ex vivo binding studies in mice, the compound had an ED50 of 0.13?mg?kg?1, subcutaneously. It promotes wakefulness in rodents at 10?mg?kg?1 s.c. but not at 1?mg?kg?1, and significantly, this effect was absent in H3 receptor KO mice. JNJ-10181457 is also a dibasic amine antagonist that exhibits high-affinity binding for the rat H3 receptor (Ki=7.1?nm), promoting wakefulness in rodents and reducing cataplectic attacks in narcoleptic dogs . JNJ-10181457 improved cognitive performance in SHR pups at 10?mg?kg?1[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : Slightly soluble
关键字: Inhibitor | JNJ-5207852 | toxicity | inhibit | JNJ5207852 | JNJ 5207852 | JNJ 5207852 Dihydrochloride | low | sleep | JNJ5207852 Dihydrochloride | REM | Histamine Receptor | JNJ5207852 dihydrochloride | JNJ-5207852 Dihydrochloride | JNJ 5207852 dihydrochloride
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途