(S)-(+)-4-苄基-3-巴豆酰基-2-噁唑烷酮 T8823
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
200 mg | 133812-16-5 | ¥2,470.00 | 询底价 |
100 mg | 133812-16-5 | ¥1,650.00 | 询底价 |
5 mg | 133812-16-5 | ¥287.00 | 询底价 |
1 mL | 133812-16-5 | ¥297.00 | 询底价 |
10 mg | 133812-16-5 | ¥428.00 | 询底价 |
25 mg | 133812-16-5 | ¥735.00 | 询底价 |
50 mg | 133812-16-5 | ¥1,090.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Locostatin
描述: Locostatin 是一种有效的细胞渗透性 Raf 激酶抑制剂蛋白 (RKIP)/Raf1 激酶相互作用抑制剂和细胞迁移抑制剂。
动物实验: Carbon tetrachloride (CCl4) was used to induce liver fibrosis in mice, and locostatin was injected intraperitoneally. Liver fibrosis was assessed by Masson and Sirius red staining, hydroxyproline (HYP) assay, and collagen percentage area. Collagen I, collagen III, and α-SMA were detected by RT-PCR and western blot. The levels of MMP-13, MMP-2, TIMP-1, and TIMP-2 were estimated by ELISA. Liver inflammation was evaluated by HE staining and immunohistochemistry; liver myeloperoxidase (MPO), superoxide dismutase, and malondialdehyde were measured by ELISA; and cytokines were by Mouse Cytokine Array Q4000[2]
体外活性: Locostatin treatment resulted in the activation of the mitogen-activated protein kinase (MAPK) signal pathway (ERK phosphorylation), providing a powerful validation of our targeting protocol. Further, RKIP inhibition by locostatin reduces ECM components. Moreover, the inhibition of RKIP by locostatin impaired cell proliferation and migration in both leiomyoma and myometrial cells. Finally, locostatin treatment reduced GSK3β expression. Therefore, even if the activation of MAPK pathway should increase proliferation and migration, the destabilization of GSK3β leads to the reduction of proliferation and migration of myometrial and leiomyoma cells[1].
体内活性: Compared to the CCl4 group, HYP (208.56 ± 6.12) μg/g, percentage of total collagen at overall region (1.91 ± 0.13), MMP-13/TIMP-1 (0.19 ± 0.01), MPO (1.45 ± 0.04) U/g, TGF-β (2652 ± 91.20), PDGF-AA (3897 ± 290.69), and E-selectin (1569 ± 66.48) in the liver tissues were decreased significantly in the locostatin-treated group[2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMF : 5 mg/ml
DMSO : 5 mg/ml
ethanol : 10 mg/ml
关键字: Locostatin
相关产品: Regorafenib monohydrate | Dabrafenib | Uplarafenib | B-Raf IN 15 | I-37 free base( 2359690-13-2(free base)) | Sorafenib tosylate | Doramapimod | Vem-L-Cy5 | Griffipavixanthone | Pseudoginsenoside Rh2
相关库: Anti-Liver Cancer Compound Library | Anti-Cancer Compound Library | Inhibitor Library | Kinase Inhibitor Library | Anti-Obesity Compound Library | Anti-Colorectal Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Reprogramming Compound Library | MAPK Inhibitor Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途