2',4'-二羟查耳酮 T8829

Product Introduction
Bioactivity


英文名: 2',4'-DIHYDROXYCHALCONE

描述: 2',4'-DIHYDROXYCHALCONE (2',4'-DHC) 作为具有 Hsp90 抑制和抗真菌作用的化合物

体外活性: In the presence of 2',4'-DHC (8 g/mL), radial growth of Aspergillus fumigatus was inhibited 20% compared to the control, and green pigmentation was completely blocked.?The expression of the conidiation-associated genes abaA, brlA, and wetA was significantly decreased (approximately 3- to 5-fold) by treatment with 2',4'-DHC.?The expression of calcineurin signaling components, cnaA and crzA, was also significantly reduced.?The inhibitory effects of 2',4'-DHC on metabolic activity and mycelial growth were significantly enhanced by combination treatment with itraconazole and caspofungin.?Docking studies indicated that 2',4'-DHC bind to the ATPase domain of Hsp90.?2',4'-DHC act as an Hsp90-calcinurin pathway inhibitor[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 11 mg/mL (45.78 mM)


关键字: 2',4'DIHYDROXYCHALCONE | 2',4' DIHYDROXYCHALCONE | 2',4'-DIHYDROXYCHALCONE

相关产品: Apoptozole | KRIBB11 | SMTIN-T140 | 4beta-Hydroxywithanolide E | TRC051384 | BIIB021 | JG-98 | Ethoxyquin | JG-231 | BX-2819

相关库: Anti-Metabolism Disease Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Fungal Compound Library | Metabolism Compound Library | Exosome Compound Library | Covalent Inhibitor Library | NO PAINS Compound Library | Bioactive Compound Library | Anti-Infection Compound Library

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