化合物CCI 007 T8838

Product Introduction
Bioactivity


英文名: CCI-007

描述: CCI 007 是一种具有细胞毒性的选择性白血病抑制剂，在MLL 重排的敏感系婴幼儿白血病细胞中，IC50为2.5-6.2 μM。

体外活性: small molecule CCI-007 was identified as a compound that selectively and significantly decreased the viability of a subset of MLL-r and related leukemia cell lines with CALM-AF10 and SET-NUP214 translocation.?CCI-007 induced a rapid caspase-dependent apoptosis with mitochondrial depolarization within twenty-four hours of treatment.?CCI-007 altered the characteristic MLL-r gene expression signature in sensitive cells with downregulation of the expression of HOXA9, MEIS1, CMYC and BCL2, important drivers in MLL-r leukemia, within a few hours of treatment.?MLL-r leukemia cells that were resistant to the compound were characterised by significantly higher baseline gene expression levels of MEIS1 and BCL2 in comparison to CCI-007 sensitive MLL-r leukemia cells.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 25 mg/mL (74.33 mM)


关键字: CCI-007 | MLL-r | CCI 007 | CALM-AF10 | HOXA9 | MEIS1 | Apoptosis | CCI007 | CMYC | SET-NUP214 | inhibit | Inhibitor

相关产品: Dehydrotrametenolic acid | Abacavir | Trametinib (DMSO solvate) | Mepazine | Hirsutine | INH1 | AZD0156 | 9-Methoxycamptothecin | GNE-900 | ZLDI-8

相关库: Bioactive Compounds Library Max | Inhibitor Library | Epigenetics Compound Library | Apoptosis Compound Library | Hematonosis Compound Library | Reprogramming Compound Library | Methylation Compound Library | Histone Modification Compound Library | Bioactive Compound Library | Chromatin Modification Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途