化合物I3MT-3 T8851

Product Introduction
Bioactivity


英文名: I3MT-3

描述: I3MT-3 (HMPSNE) 是一种有效的、具有细胞膜渗透性的、选择性的 3-巯基丙酮酸硫转移酶 (3MST)的抑制剂，IC50值为2.7 μM，对其他硫化氢/磺胺制硫酶没有活性。它靶向位于 3MST 活性位点的过硫半胱氨酸残基。

体外活性: I3MT-3 shows a dose-dependent inhibition of 3-MST activity from CT26 homogenates, which contain the murine form of the enzyme. The IC50 of HMPSNE for murine 3-MST is calculated as 2.3 μM with a cozncentration-dependent decrease of AzMC fluorescence[1].I3MT-3 (0-300 μM; 48 hours) inhibits CT26 cells proliferate with increasing concentrations of I3MT-3. Confluence of cells treated with HMPSNE is recorded each hour for 48 h by the IncuCyte method[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 120mg/mL (386.64mM)


关键字: EA.hy926 cells | Hippo (MST) | inhibit | 3MST | I3MT-3 | HEK293 | I3MT3 | cell-membrane | COS-7 | I-3MT-3 | I3MT 3 | Inhibitor

相关产品: XMU-MP-1 | Cerdulatinib hydrochloride | IHMT-MST1-58 | Pim1/AKK1-IN-1

相关库: Anti-Prostate Cancer Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Kinase Inhibitor Library | Stem Cell Differentiation Compound Library | NO PAINS Compound Library | Covalent Inhibitor Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途