5-碘异喹啉 T8860

Product Introduction
Bioactivity


英文名: DSRM-3716

描述: DSRM-3716 是选择性的SARM1 NADase 抑制剂，IC50为 75 nM，相较于其他 NAD+加工酶、受体和转运蛋白具有选择性。DSRM-3716显示出强大的轴突保护作用。

体外活性: Treatment with the isoquinoline Isoquinoline, 5-iodo- (9CI) produced dose-dependent inhibition of cADPR increase (IC50 = 2.8 μM) and substantial preservation of NAD+ in these cultures in a manner consistent with engagement and inhibition of SARM1 enzymatic NADase activity inside the cells. Isoquinoline, 5-iodo- (9CI) prevented NfL release from severed axons in a dose-dependent manner[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (196.03 mM)


关键字: SARM1 | DSRM-3716 | NADase | DSRM3716 | neurodegenerative | cADPR | DSRM 3716 | Inhibitor | 5-Iodoisoquinoline | axon | inhibit

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相关库: Anti-Prostate Cancer Compound Library | Transcription Factor-Targeted Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Nuclear Receptor Compound Library | Endocrinology-Hormone Compound Library | Bioactive Compound Library

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