化合物GSK046 T8932

Product Introduction
Bioactivity


英文名: GSK046

描述: GSK046 (iBET-BD2) 是一种选择性和具有口服活性的 BET 蛋白 BD2溴结构域的抑制剂，对 BRD2 BD2、BRD3 BD2、BRD4 BD2 和 BRDT BD2的 IC50值为 264、98、49 和 214 nM，具有免疫调节活性。

体内活性: GSK046 (40 mg/kg/QD;?s.c. for 14 days) has immunomodulatory activity.?GSK046 exhibits Cmax (C57BL6 1589, C57B16 2993 ng/mL) and terminal elimination half-lives (C57BL6 1.8, C57B16 1.9 h) following oral administration (C57BL6 10, C57B16 40 mg/kg).?GSK046 exhibits Cmax (mouse 1589, rat 202 ng/mL) and terminal elimination half-lives (mouse 1.8, rat 1.4 h) following oral administration (mouse 10, rat 10 mg/kg)[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 83.33 mg/mL (201.05 mM)


关键字: GSK-046 | Epigenetic Reader Domain | BRDT | BRD2 | inhibit | GSK046 | immuno-inflammation | BRD4 | GSK 046 | Inhibitor | BD2 | BRD3

相关产品: SRX3177 | ODM-207 | PROTAC BRD9-binding moiety 1 | ZL0454 | Bromosporine | GSK778 hydrochloride | MI-503 | ACBI1 | GNE-375 | FL-411

相关库: Bioactive Compounds Library Max | Inhibitor Library | Epigenetics Compound Library | PPI Inhibitor Library | Orally Active Compound Library | Reprogramming Compound Library | NO PAINS Compound Library | Histone Modification Compound Library | Bioactive Compound Library

化合物GSK046 T8932信息由TargetMol中国为您提供，如您想了解更多关于化合物GSK046 T8932报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途