化合物BDTX-189 T9072

Product Introduction
Bioactivity


英文名: Tuxobertinib

描述: Tuxobertinib (BDTX-189) 是一种高效可口服的选择性 EGFR 和 HER2变构突变抑制剂，具有抗癌活性。它对 EGFR、HER2、BLK 和 RIPK2 的 KD 值分别为 0.2、0.76、13 和 1.2 nM。

体内活性: BDTX-189 (0-100 mg/kg;?p.o.;?daily for 15 dyas) shows dose-dependent tumor growth inhibition and regression in in athymic nude mice bearing HER2 S310F Ba/F3 allograft tumors.?BDTX-189 (1-50 mg/kg.p.o.;?daily for 15 days) shows dose-dependent tumor growth inhibition and regression in athymic nude mice bearing CUTO-14 PDX tumors that express the EGFR mutation EGFR ASV

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 41.67 mg/mL (74.27 mM)


关键字: inhibit | BDTX189 | ErbB-1 | EGFR | mutants | Epidermal growth factor receptor | nude | allosteric | Ba/F3 | BDTX 189 | HER1 | Tuxobertinib | oncogene athymic | oral | mice | insertion | Inhibitor

相关产品: Dacomitinib | EGFR/BRAFV600E-IN-3 | EGFR-IN-9 | WS6 | 2′-Thioadenosine | EBE-A22 | Afatinib | AG 555 | BI-4020 | Mobocertinib

相关库: Drug Repurposing Compound Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | Anti-Lung Cancer Compound Library | Inhibitor Library | Kinase Inhibitor Library | Anti-Cancer Clinical Compound Library | Tyrosine Kinase Inhibitor Library | Anti-Cancer Active Compound Library | Reprogramming Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途