化合物TJ191 T9104

Product Introduction
Bioactivity


英文名: TJ191

描述: TJ191 是一种选择性抗癌试剂，靶向低 TβRIII 表达的恶性T 细胞白血病/淋巴瘤细胞，可研究癌症。

体外活性: TJ191 (0.1-3 μM; 8 or 24 hours) induces CEM cell apoptosis in a concentration- and time-dependent manner. Even at 0.3 μM, TJ191 induces the maximum apoptotic rate of 80% after 24 h.?TJ191(0-100 μM; 24 hours) exhibits pronounced anti-proliferative activity in malignant cell lines, the IC50 values are 0.13 μM, 0.13±0.08 μM, 0.26±0.19 μM, 0.22±0.11 μM, 1.5±0.02 μM, 0.32±0.086 μM, 3.1±0.5 μM, 0.26±0.16 μM in CEM, JURKAT, MOLT-3, MOLT-4, SUP-T1, MT-2, C8166 and HSB-2 cells, respectively. But has no effects in HUT-78 (IC50=17±10 μM) and MT-4 (IC50=47 ± 5 μM) cells.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 55 mg/mL (215.37 mM)


关键字: cancer | Apoptosis | PMBC | MOLT-3 | CEM | inhibit | C8166 | Inhibitor | MOLT-4 | MT-2 | TJ 191 | TJ-191 | TJ191 | HSB-2 | SUP-T1 | JURKAT

相关产品: PD168393 | TVB-3166 | Bendamustine | Talampanel | MYCMI-6 | DCH36_06 | Tetrahydroxyquinone | Quercetin | Dehydrocrenatidine | Vatalanib dihydrochloride

相关库: Anti-Cancer Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library | Hematonosis Compound Library | Apoptosis Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途