化合物MRT68921 dihydrochloride T9142

Product Introduction
Bioactivity


英文名: MRT68921 dihydrochloride

描述: MRT68921 dihydrochloride 有效抑制ULK1和ULK2，IC50值分别为 2.9 nM 和 1.1 nM。

体外活性: MRT68921 inhibits ULK1 and ULK2 in vitro and block autophagy in cells.?MRT68921 is the most potent inhibitor of both ULK1 and ULK2, with greater than a 15-fold reduction in the IC50 for ULK1 (2.9 nm) and greater than a 30-fold reduction for ULK2 (1.1 nm).?Autophagy-inhibiting capacity of the compounds is specifically through ULK1.?ULK1 inhibition results in accumulation of stalled early autophagosomal structures, indicating a role for ULK1 in the maturation of autophagosomes as well as initiation[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 33.33 mg/mL (65.67 mM)
DMSO : 2 mg/mL (3.94 mM)


关键字: inhibit | MRT-68921 | ULK | MRT-68921 dihydrochloride | MRT68921 | Inhibitor | MRT 68921 | Unc-51 like kinase | MRT68921 dihydrochloride | MRT 68921 Dihydrochloride | MRT-68921 Dihydrochloride | MRT68921 Dihydrochloride

相关产品: LY2109761 | PHA-665752 | (-)-Epigallocatechin | LYS01 | GC7 Sulfate | Sitagliptin | Rutin | Oxaliplatin | Metformin | WYC-209

相关库: Bioactive Compounds Library Max | Inhibitor Library | Kinase Inhibitor Library | Autophagy Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途